Inflammatory Manifestations of Lymphedema
Identifieur interne : 000478 ( Main/Exploration ); précédent : 000477; suivant : 000479Inflammatory Manifestations of Lymphedema
Auteurs : Catherine L. Ly ; Raghu P. Kataru ; Babak J. MehraraSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Cellules dendritiques, Cytokines (immunologie), Cytokines (métabolisme), Humains, Inflammation (), Inflammation (immunologie), Inflammation (métabolisme), Lymphocytes T CD4+, Lymphoedème (), Lymphoedème (immunologie), Lymphoedème (métabolisme), Macrophages, Modèles animaux de maladie humaine, Système lymphatique (anatomopathologie), Système lymphatique (immunologie), Système lymphatique (métabolisme).
- MESH :
- anatomopathologie : Système lymphatique.
- immunologie : Cytokines, Inflammation, Lymphoedème, Système lymphatique.
- métabolisme : Cytokines, Inflammation, Lymphoedème, Système lymphatique.
- Animaux, Cellules dendritiques, Humains, Inflammation, Lymphocytes T CD4+, Lymphoedème, Macrophages, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- Animals, CD4-Positive T-Lymphocytes, Cytokines (immunology), Cytokines (metabolism), Dendritic Cells, Disease Models, Animal, Humans, Inflammation (immunology), Inflammation (metabolism), Inflammation (therapy), Lymphatic System (immunology), Lymphatic System (metabolism), Lymphatic System (pathology), Lymphedema (immunology), Lymphedema (metabolism), Lymphedema (therapy), Macrophages.
- MESH :
- chemical , immunology : Cytokines.
- chemical , metabolism : Cytokines.
- immunology : Inflammation, Lymphatic System, Lymphedema.
- metabolism : Inflammation, Lymphatic System, Lymphedema.
- pathology : Lymphatic System.
- therapy : Inflammation, Lymphedema.
- Animals, CD4-Positive T-Lymphocytes, Dendritic Cells, Disease Models, Animal, Humans, Macrophages.
Abstract
Lymphedema results from lymphatic insufficiency leading to a progressive inflammatory process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary malignancy. Collectively, these morbidities contribute to an overall poor quality of life. Although there have been recent advances in microsurgical interventions, a conservative palliative approach remains the mainstay of treatment for this disabling disease. The absence of a cure is due to an incomplete understanding of the pathophysiological changes that result in lymphedema. A histological hallmark of lymphedema is inflammatory cell infiltration and recent studies with animal models and clinical biopsy specimens have suggested that this response plays a key role in the pathology of the disease. The purpose of this report is to provide an overview of the ongoing research in and the current understanding of the inflammatory manifestations of lymphedema.
Url:
DOI: 10.3390/ijms18010171
PubMed: 28106728
PubMed Central: 5297803
Affiliations:
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Ly</name></author><author><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P." last="Kataru">Raghu P. Kataru</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>CD4-Positive T-Lymphocytes</term><term>Cytokines (immunology)</term><term>Cytokines (metabolism)</term><term>Dendritic Cells</term><term>Disease Models, Animal</term><term>Humans</term><term>Inflammation (immunology)</term><term>Inflammation (metabolism)</term><term>Inflammation (therapy)</term><term>Lymphatic System (immunology)</term><term>Lymphatic System (metabolism)</term><term>Lymphatic System (pathology)</term><term>Lymphedema (immunology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (therapy)</term><term>Macrophages</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules dendritiques</term><term>Cytokines (immunologie)</term><term>Cytokines (métabolisme)</term><term>Humains</term><term>Inflammation ()</term><term>Inflammation (immunologie)</term><term>Inflammation (métabolisme)</term><term>Lymphocytes T CD4+</term><term>Lymphoedème ()</term><term>Lymphoedème (immunologie)</term><term>Lymphoedème (métabolisme)</term><term>Macrophages</term><term>Modèles animaux de maladie humaine</term><term>Système lymphatique (anatomopathologie)</term><term>Système lymphatique (immunologie)</term><term>Système lymphatique (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cytokines</term><term>Inflammation</term><term>Lymphoedème</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Inflammation</term><term>Lymphatic System</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Lymphatic System</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Inflammation</term><term>Lymphoedème</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Inflammation</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>CD4-Positive T-Lymphocytes</term><term>Dendritic Cells</term><term>Disease Models, Animal</term><term>Humans</term><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules dendritiques</term><term>Humains</term><term>Inflammation</term><term>Lymphocytes T CD4+</term><term>Lymphoedème</term><term>Macrophages</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphedema results from lymphatic insufficiency leading to a progressive inflammatory process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary malignancy. Collectively, these morbidities contribute to an overall poor quality of life. Although there have been recent advances in microsurgical interventions, a conservative palliative approach remains the mainstay of treatment for this disabling disease. The absence of a cure is due to an incomplete understanding of the pathophysiological changes that result in lymphedema. A histological hallmark of lymphedema is inflammatory cell infiltration and recent studies with animal models and clinical biopsy specimens have suggested that this response plays a key role in the pathology of the disease. The purpose of this report is to provide an overview of the ongoing research in and the current understanding of the inflammatory manifestations of lymphedema.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Warren, A G" uniqKey="Warren A">A.G. Warren</name></author><author><name sortKey="Brorson, H" uniqKey="Brorson H">H. 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Engeset</name></author><author><name sortKey="Romaniuk, A" uniqKey="Romaniuk A">A. Romaniuk</name></author><author><name sortKey="Grzelak, I" uniqKey="Grzelak I">I. Grzelak</name></author><author><name sortKey="Ziolkowska, A" uniqKey="Ziolkowska A">A. Ziolkowska</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P." last="Kataru">Raghu P. Kataru</name><name sortKey="Ly, Catherine L" sort="Ly, Catherine L" uniqKey="Ly C" first="Catherine L." last="Ly">Catherine L. Ly</name><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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